Table 2.

Approximate IC₅₀ values for conantokins tested against various NR2 subunits.

Peptide	NR2A IC50 (μM)	NR2B IC50 (μM)	NR2C IC50 (μM)	NR2D IC50 (μM)	NR2D/NR2B IC50 Ratio	NR2C/NR2B IC50 Ratio
Con-P	2.3	0.3	≫ 10	≥ 10	> 10	≫10
Con-R	~1	1.0	7.3	≫ 10	≫ 10	7.3
Con-G	≫ 10	0.1	1	1	10	10
Con-Pr1	≫ 10	0.2	≥ 10	1	5	≥ 10
Con-Pr2	≫ 10	0.5	≥ 10	1	2	≥ 10
Con-Pr3	≫ 10	0.5	≥ 10	8	16	≥ 10

Con-P IC₅₀ values were obtained from the concentration-response curves in Fig. 6; data for Con-Pr1, Con-Pr2, Con-Pr3, and Con-G were obtained from Teichert et al., (2007); data for Con-R obtained using NR1-1b subunit in combination with NR2 subunits (White et al., 2000).