Table 2.
Behavioral and neurochemical characteristics features of MAO A, MAO B and MAO AB KO mice (compare to WT)
| Phenotypical features | MAO A KO | MAO B KO | MAO AB KO | |
|---|---|---|---|---|
| Neurotransmitter levels | 5-HT (serotonin) | 200% ↑ | - | 700% ↑ |
| NE (norepinephrine) | 130% ↑ | - | 200% ↑ | |
| DA (dopamine) | 110% ↑ | - | 200% ↑ | |
| PEA (phenylethylamine) | - | 700% ↑ | 1400% ↑ | |
| Locomotor activity | Open field | ↓ | - | ↓↓ |
| Startle reactivity | ↓ | ? | ? | |
| Aggression | Resident-intruder aggression | ↑↑ | - | ↑ |
| Aggression in familiar environment | ↑ | - | ↑ | |
| Anxiety and fear | Plus-maze anxiety | - | - | ↑ |
| Open-field anxiety (periphery/center ratio) | - | - | ↑↑ | |
| Fear conditioning | ↑ | ? | ? | |
| Depression | Immobility time in forced swim test | ↓ | ↓ | ? |
| Immobility time in tail suspension test | ↓ | ? | ? | |
Keys: ↑: increase; ↓: decrease; -: no change; ?: unknown.