Figure 8.

Echocardiographic measurement of pulmonary hypertensive parameters in animals serially investigated after MCT exposure at day 0, the establishment of reliable pathologies at day 17, and the dosing of either vehicle, or SB525334 from days 17 to 35 (noted above). RV wall thickness during systole (A) and diastole (B), pulmonary artery acceleration time (C) and degree of midsystolic notch (D) are shown. Vehicle versus MCT-exposed; vehicle-treated groups are represented by open and closed circles, respectively. Treated groups are shown by dashed lines at 3 mg/kg (closed triangle) and 30 mg/kg (closed square). Values are means ± SEM. *P < 0.01 versus day 35 vehicle-treated control (one-way analysis of variance and Kruskal-Wallis test).