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. 2009 Feb;174(2):390–400. doi: 10.2353/ajpath.2009.080513

Figure 10.

Figure 10

IL-31 and IL-31RA expression in the CRA model and their role in TERT induction. A: Lung IL-31 and IL-31RA mRNA levels were measured by real-time PCR at 6 hours after final allergen challenge. Results are expressed as described in the legend to Figure 9. B: CD11b-negative lung fibroblasts isolated from control or CRA (allergen)-challenged mice were analyzed also for IL-31RA or IL-31RA plus collagen I expression by flow cytometry. C: IL-31RA mRNA levels were measured by real-time PCR in GFP+ or GFP− CD11b-negative lung fibroblasts isolated from CRA-challenged GFP bone marrow chimera mice. D: The effect of SCF treatment on bone marrow cell IL-31RA mRNA levels was examined using real-time PCR. E: Finally the effect of IL-31 stimulation on lung fibroblast TERT mRNA levels was analyzed using real-time PCR. A and B: Significance (*#P < 0.05) compared with whole lung cells from naïve animals. C: Significance compared with mean signal in untreated GFP-negative cells. D and E: Significance (*P < 0.05) compared with untreated control. N = 6 animals per group.