Figure 6.

Effects of anti-SCF antibody treatment on airway remodeling. A: Shown are the days of anti-SCF antibody administration in the GFP bone marrow chimera and CRA asthma mice model. B: Administration of anti-SCF antibodies abrogates CRA-induced influx of bone marrow-originated cells into lungs. C: Lungs of mice from the indicated treatment groups were inflated and processed as described. Serial cryostat sections were analyzed within 1 hour for presence of GFP-positive cells in the lung tissue sections. Representative sections from control (Con panel), CRA-challenged (CRA panels), and CRA plus anti-SCF antibody-treated mice (CRA + αSCF panel) are shown. D: Representative lung tissue sections from mice in the indicated treatment groups were stained for collagen using the Masson trichrome stain. Significant remodeling in CRA-challenged mice with mucus plugs was significantly reduced in mice also treated with anti-SCF antibodies. N = 12 animals per group.