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. 2009 Feb;174(2):460–474. doi: 10.2353/ajpath.2009.080462

Figure 3.

Figure 3

Fn14-TRAIL suppresses MOG-induced autoimmune encephalomyelitis. A: Serum levels of Fn14, Fn14-TRAIL, Fn14-IgG1(mut), and TRAIL were measured by ELISA 20 days after hydrodynamically injecting 50 μg of the respective pSBC21-based expression plasmids. B: Eight to nine mice per group were challenged with MOG in CFA supplemented with M. tuberculosis as described in the Material and Methods. Forty-eight hours after MOG challenge, mice were hydrodynamically injected with 50 μg of the indicated pSBC21-based expression constructs. Individual mice were scored according to the clinical scale described in the Materials and Methods. Parameters evaluated include mean clinical score (B, top) and disease incidence (B, bottom). The difference between the Fn14-TRAIL-treated versus vector-only control group is statistically significant according to the Mann-Whitney U-test (P < 0.05), where the differences between the other groups shown and the vector-only group are not significant (see Table 1, which is based on the same experiment). The data shown are representative of at least three independent experiments.