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. 2009 Feb;174(2):613–629. doi: 10.2353/ajpath.2009.080653

Figure 3.

Figure 3

Figure 3

Cav-3−/− virgin mammary glands show evidence of a constitutive lactogenic phenotype. A: Transcriptional expression of more than 170 pregnancy-associated genes was changed in Cav-3−/− virgin mammary glands. Hierarchical clustering of these gene changes is shown. These genes are listed in Table 2. Green indicates down-regulated; red indicates up-regulated. B: Paraffin-embedded sections derived from wild-type (WT) and Cav-3−/− virgin female mammary glands were immunostained with antibodies directed against mouse milk proteins (β-casein and WAP). C: Paraffin-embedded sections derived from WT and Cav-3−/− virgin female mammary glands were immunostained with antibodies directed against Stat5a. Note that Cav-3−/− mammary glands overexpress a number of gene products associated with lactation and milk production, including mouse milk proteins (β-casein and WAP) and Stat5a. Similar results were obtained with young (2 months old) and older mice (4 and 8 months old). Scale bars = 50 μm.