Table 1.
Demographic Characteristics and Stage Distribution of 70 Patients with Non-Small Cell Lung Cancer, with Groups Separated by the Presence or Absence of CD74 Immunoreactivity
| CD74-positive (n = 57) | CD74-negative (n = 13) | P value | |
|---|---|---|---|
| Age | 64.2 ± 8.6 | 62.4 ± 9.5 | NS |
| Sex (% male) | 54% | 55% | NS |
| Stage | NS | ||
| I | 32 | 11 | |
| II | 1 | 1 | |
| III | 7 | 1 | |
| IV | 4 | 0 | |
| % Nonsmokers | 16% (9 of 57) | 15% (2 of 13) | NS |
| Adenocarcinoma | 35 | 8 | NS |
| Squamous | 19 | 5 | NS |
| Other (two large cell neuroendocrine, one small cell) | 3 | 0 | NS |
| Vessel density (vessels per high-power field, mean ± SE) | 36.1 ± 3.2 | 22.9 ± 3.8 | 0.02 |
| Angiogenic CXC chemokines (ELR score; ng/mg total protein) | 95.6 ± 34.4 | 8.8 ± 3.2 | 0.05 |
Vessel density and levels of angiogenic ELR CXC chemokines in lung cancer tumors are higher in tumors where CD74 was present by immunohistochemistry. NS = nonsignificant.