Figure 9. Immune sera can protect normal mice even when given 24 hours post-infection.
Mice (normal/naïve) were challenged intra-nasally with approximately 3 LD50 doses (109 CFU) of SCHU S4. At 24 hours post-infection, mice were then given 250 μl of serum from either control mice or immune sera from mice challenged with SCHU S4 and treated with levofloxacin at 72 hours post challenge, as described in Figure 8. Mice were monitored twice daily for up to one month. Asterisk indicates statistically significant survival with p<0.0005