TABLE 2.
Parametric 90% CIs for the mean pharmacokinetic properties of dihydroartemisinin and piperaquine after the administration of a single oral dose of Arterakine and Artekin (reference formulation)
| Drug and parameter | Arterakine/Artekin point estimator (%) | 90% CIa |
|---|---|---|
| Dihydroartemisinin | ||
| Cmax | 136.4 | 100.6-152.8b |
| AUC0-last | 122.0 | 105.4-137.3b |
| AUC0-∞ | 121.6 | 105.0-137.3b |
| Cmax/AUC0-∞ | 105.9 | 92.9-114.8 |
| t1/2 | 95.2 | 88.7-105.3 |
| Piperaquine | ||
| Cmax | 116.5 | 91.3-142.0b |
| AUC0-last | 111.7 | 101.6-123.6 |
| AUC0-∞ | 115.4 | 106.5-128.5b |
| Cmax/AUC0-∞ | 97.7 | 78.3-121.3 |
| t1/2 | 100.6 | 86.4-125.2b |
a
Determined by using log-transformed data.
b
Value falls outside the range of 80 to 125%.