FIG. 1.

Mean POS concentrations in plasma, ELF, and ACs. Shown are concentration-time profiles for POS on day 8 after healthy subjects received POS (400 mg; 40-mg/ml oral suspension) every 12 h with food (10 min after eating a high-fat meal) for a total of 14 doses. Note that only the plasma data has error bars (± SD), as the data were obtained from multiple subjects at the same time. The ELF and AC data were obtained as one data value per subject. The MIC₉₀ value for Aspergillus spp. was obtained from the recent literature (19).