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Plasma, ELF, and AC PK/PDa parameters
| Compartment | Cmin (μg/ml) | Cmaxb (μg/ml) | Cmax/MIC90 ratio | Tmax (h) | AUC0-12 (μg·h/ml) | AUC0-24/MIC90 ratioc |
|---|---|---|---|---|---|---|
| Plasma | 1.54 | 2.08 ± 0.93 | 4.15 | 3.6 | 21.9 | 87.6 |
| ELF | 1.02 | 1.86 ± 1.30 | 3.72 | 5.0 | 18.3 | 73.2 |
| AC | 46.2 | 87.7 ± 65.0 | 175 | 5.0 | 715 | 2,860 |
The parameters were derived using total (i.e., unbound plus bound) drug concentrations (see the text).
Mean values ± SD are shown.
Based on the AUC0-24, which was twice the AUC0-12.
