TABLE 2.
IC50s of EA, FEA, and CEA on isolated P. falciparum and human redox enzymes
| Inhibitor | IC50 (μM)
|
|||||||
|---|---|---|---|---|---|---|---|---|
| GST
|
GR
|
TrxR (Trx assay)
|
TrxR (DTNB assay)
|
|||||
| P. falciparum | Human | P. falciparum | Human | P. falciparum | Human | P. falciparum | Human | |
| EA | 74.4 ± 6.1 | 77.1 ± 4.4 | 27.6 ± 2.8 | 22.8 ± 3.2 | 66.7 ± 3.2 | 78.3 ± 5.1 | 137.8 ± 17.3 | 275.3 ± 35.0 |
| FEA | 29.3 ± 5.4 | 35.7 ± 3.9 | 16.3 ± 1.8 | 26.7 ± 5.8 | 21.7 ± 2.9 | 41.7 ± 3.9 | 35.3 ± 6.7 | 51.7 ± 2.9 |
| CEA | 7.0 ± 2.1 | 35.1 ± 4.1 | 14.6 ± 4.2 | 7.6 ± 1.2 | 6.8 ± 0.3 | 3.0 ± 0.6 | 23.8 ± 4.8 | 4.2 ± 1.1 |