TABLE 2.
Vancomycin exposure based on changes in audiogram results during vancomycin therapya
| Patient group (n)b | Daily vancomycin dose (g) | Highest vancomycin trough level (mg/liter) | Duration of vancomycin therapy (days)
|
|
|---|---|---|---|---|
| Total | Prior to follow-up audiogram | |||
| All (89) | 1.7 ± 0.6 (2.0) | 19 ± 7 (17) | 28 ± 14 (28) | 27 ± 23 (21) |
| No change in audiogram (78) | 1.7 ± 0.7 (2.0) | 19 ± 7 (17) | 28 ± 15 (28) | 28 ± 25 (21) |
| Worsening audiogram (11) | 1.8 ± 0.6 (2.0) | 20 ± 8 (20) | 25 ± 15 (20) | 25 ± 9 (25) |
a
Data are means ± standard deviations (medians).
b
None of the variables measured showed significant differences between the patient groups (P values, 0.575 for the daily vancomycin dose, 0.524 for the highest vancomycin trough level, 0.712 for the total duration of vancomycin therapy, and 0.477 for the duration of vancomycin therapy prior to the follow-up audiogram).