TABLE 3.

Characteristics of patients with audiogram changes during vancomycin therapy^a

Age (yr)	Sex	Race	Serum creatinine concn (mg/dl)	Range of VAN trough levels (mg/liter)	VAN indication	Days of VAN at time of follow-up audiogram	Audiogram result		VAN 24-h dose (durationb)	Other ototoxins
							Baseline	Follow-up
71	M	White	0.5-0.9	10.9-34.9	Osteomyelitis	40	Mod to severe bilat SNHL	Severe bilat SNHL	1 g q12h (40 days)	None
59	F	White	0.5	7.9-12.3	MRSA bacteremia	35	Normal	R, no change; L, severe SNHL	1 g q12h (35 days)	None
74	M	Hispanic	0.9	8.8-9.8	Osteomyelitis	17	Mild bilat SNHL	Severe bilat SNHL	1.5 g q12h (17 days)	None
74	F	White	4.0-4.9	22-23	Osteomyelitis	16	Mild to mod R SNHL	Mod to severe R SNHL	By serum concns (16 days)	Gentamicin, 6 days
59	F	White	0.9	20-21	Sternal wound infection	35	Mild to mod bilat SNHL	Mod to severe bilat SNHL	750 mg q12h (35 days)	None
83	M	White	1.2	10-15	Soft tissue infection	15	Mild to mod bilat SNHL	Severe bilat SNHL	1 g q24h (15 days)	None
66	F	White	0.5	2.5-18.1	Osteomyelitis	27	Mild bilat SNHL	Severe bilat SNHL	1 g q12h (27 days)	None
60	M	Black	1.3-1.7	15	MRSA pneumonia	20	Mild bilat SNHL	Mod bilat SNHL	1 g q24h (20 days)	None
71	M	White	HD	15.1-20.1	MRSA bacteremia	25	Mod to severe bilat SNHL	Profound bilat SNHL	By serum concns (25 days)	None
53	M	Hispanic	0.7-1.1	19-31	Soft tissue infection	21	Normal	R, normal; L, mod SNHL	1 g q12h (21 days)	Furosemidec
65	F	Black	0.8	15-22	MRSA soft tissue bacteremia	25	Mild bilat SNHL	Mod bilat SNHL	1 g q12h (25 days)	Furosemidec

^aAbbreviations: M, male; F, female; VAN, vancomycin; mod, moderate; bilat, bilateral; R, right; L, left; SNHL, sensorineural hearing loss; q12h, every 12 h.

^bDuration of vancomycin therapy before follow-up audiogram.

^cStanding-order baseline medication of indefinite duration, not new.