(A) PFGE (SpeI restricted) of 14 representative KPC-3-producing, carbapenem-resistant K. pneumoniae isolates from various Israeli hospitals (lanes 1 to 14) demonstrates a nationwide epidemic clone different from a KPC-2-producing clone reported previously in our hospital (6) (lane 15). (B) Genetic relatedness of the predominant Israeli epidemic clone (lane 10) with nine KPC-3-producing K. pneumoniae isolates involved in outbreaks in the United States, from New Jersey (NJ; lanes 1 and 2), Arizona (AZ; lanes 3 to 5), and New York (NY; lanes 6 to 9). M, lambda ladder (New England Biolabs).