A comparison of blaKPC-3-encoding plasmids (A) and their EcoRI restriction patterns (B) from five Israeli K. pneumoniae isolates (lanes 1 to 5 in each panel) and five of the nine genetically related K. pneumoniae U.S. isolates (lanes 6 to 10 in each panel). Analysis was performed on plasmids isolated from E. coli GeneHogs transformants carrying the blaKPC-3-encoding plasmids. Lanes 1 to 5, representative Israeli isolates from 2006 to 2008; lanes 6 to 10, representative U.S. isolates from 2000 and 2006; lanes 6 and 7, two isolates from a New York medical center; lanes 8 to 10, one isolate from New Jersey and two isolates from Arizona. For panel A, lane M is a BAC-Tracker supercoiled DNA ladder (Epicentre Biotechnologies); for panel B, lane M is a GeneRuler 1-kb DNA ladder (Fermentas Life Sciences).