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Effects of treatment with mesoionic compounds (MI-4-OCH3, MI-H-H) and meglumine antimoniate on lymph node (A) and on spleen (B) parasite numbers. CBA/J mice were inoculated with L. amazonensis promastigotes and treated with the mesoionic compounds for 4 weeks. The popliteal lymph nodes and spleens of seven animals were then removed, and parasite numbers were estimated by the limiting-dilution technique (*, P < 0.0001; **, P < 0.001).
