TABLE 3.
Distribution of β-lactamases in strain collection
| Organism (total no. of isolates) | Regiona | Countryb | No. of isolates | β-Lactamase derivative(s) identifiedc
|
AmpC, C'pased | |||
|---|---|---|---|---|---|---|---|---|
| CTX-M | SHVe | TEM | OXA | |||||
| E. coli (98) | AP | CHN | 10 | 2, 3, 5, 14, 15, 22, 28 | 1, 2a, 5, 11, 12 | 1 | 1, 5, 10 | DHA-1 |
| AP | TWN | 3 | 2, 5 | 1, 5 | 1 | CMY-2 | ||
| AP | AUS | 2 | ACT-1 | |||||
| EE | BGR | 4 | 2, 15 | 5, 11, 12 | 1 | 1, 5 | ACT-1 | |
| EE | HRV | 1 | 5 | 1 | 1, 5 | |||
| EE | HUN | 1 | 1 | ACT-1 | ||||
| EE | LTU | 2 | 2, 3, 15 | 12 | ||||
| EE | POL | 1 | 2, 5 | 1 | 1 | |||
| EE | ROM | 3 | 2, 5, 15 | 1 | 1 | |||
| EE | RUS | 4 | 2, 3, 5, 15, 22, 28 | 1 | 1 | ACT-1 | ||
| EE | SVK | 1 | 2 | 5 | 1 | |||
| EE | UKR | 22 | 2, 3, 5, 14, 15, 22, 28 | 1, 5, 12 | 1 | 1, 2, 10 | ACT-1, DHA-1 | |
| IND | IND | 25 | 2, 5, 15, 28 | 1, 2a, 5, 11, 12 | 1, 2 | 1 | ACT-1, MIR-1, KPCf | |
| LA | CHL | 4 | 2, 5, 15 | 1 | 1, 5 | |||
| LA | GTL | 3 | 15, 28 | 2a, 11 | 1 | 1 | ||
| LA | MEX | 5 | 2, 5, 15 | 5, 12 | 1 | 1 | ACT-1, CMY-2, DHA | |
| NA | USA | 2 | 5 | 12 | CMY | |||
| WE | BEL | 1 | 5 | 1 | ||||
| WE | ESP | 4 | 2, 5, 15, 28 | 5, 12 | 1 | 1 | ||
| K. pneumoniae (153) | AP | CHN | 7 | 2, 5, 12, 14, 15 | 1, 5, 11, 12 | 1 | ||
| AP | KOR | 5 | 14 | 1, 5, 11, 12 | 1 | 1 | DHA-1 | |
| AP | TWN | 4 | 2, 5 | 1, 5, 11, 12 | 1 | 10 | DHA-1 | |
| EE | BGR | 3 | 5, 15 | 1, 5, 12, 28 | 1 | |||
| EE | CZE | 1 | 28 | 29 | ||||
| EE | HRV | 2 | 5 | 11 | 1 | 1 | ||
| EE | LTU | 3 | 2 | 2, 2a, 5, 11, 12 | 1 | 2 | ||
| EE | LVA | 1 | 1, 2a | 1 | ||||
| EE | ROM | 11 | 2, 5, 15 | 1, 5, 11, 12, 45 | 1 | 1 | DHA | |
| EE | RUS | 6 | 2, 5, 14, 15 | 1, 11, 12, 33 | 1 | 10 | ||
| EE | SVK | 5 | 2, 28 | 11 | 1, 110, 116 | 1 | ||
| EE | UKR | 33 | 2, 3, 5, 14, 15, 28 | 1, 2, 2a, 5, 11, 12, 28, 63 | 1 | 1, 2, 5 | KPC-3, DHA | |
| IND | IND | 33 | 2, 5, 15, 28 | 1, 2a, 5, 11, 12, 28 | 1 | 1, 2, 5, 10 | KPC | |
| LA | ARG | 8 | 2 | 1, 5, 11 | 1 | 1, 2, 10 | ||
| LA | BRA | 12 | 2, 15 | 1, 5, 11, 12 | 1, 12 | 1, 2, 5, 10 | KPC, KPC-3 | |
| LA | CHL | 5 | 2 | 1, 5, 27 | 1 | 5, 10 | ||
| LA | MEX | 2 | 15 | 1, 2a | 1 | |||
| LA | PER | 1 | 2a | |||||
| NA | USA | 5 | 2, 5 | 5, 11, 12 | 1 | KPC-2, DHA | ||
| AFR | MOR | 2 | 2, 5 | 5 | 1, 29 | |||
| AFR | ZAF | 3 | 2, 15 | 1, 5, 11 | 1 | ACT-1 | ||
| WE | GRC | 1 | 5 | |||||
| P. mirabilis (21) | EE | LVA | 1 | 1 | ACT-1/MIR-1 | |||
| EE | POL | 1 | 5 | 1 | ||||
| EE | ROM | 7 | 15, 28 | 1, 2, 5, 12 | 1, 2, 110 | 2 | CMY-2, DHA | |
| EE | RUS | 1 | 2 | 5 | 2 | |||
| EE | UKR | 1 | 14, 15 | 1 | ||||
| IND | IND | 5 | 2, 5, 28 | 1, 5, 11, 12 | 1 | 1 | DHA | |
| LA | BRA | 2 | 2, 15 | 1 | ACT-1/MIR-1 | |||
| LA | CHL | 2 | 2 | 1, 5, 11, 12 | 1 | 1, 2 | ||
| NA | USA | 1 | 155 | |||||
AFR, Africa; AP, Asia Pacific; EE, Eastern Europe; IND, India; LA, Latin America; NA, North America; WE, Western Europe.
ARG, Argentina; AUS, Australia; BEL, Belgium, BGR, Bulgaria; BRA, Brazil; CHL, Chile; CHN, China; CZE, Czech Republic; ESP, Spain; GRC, Greece; GTL, Guatemala; HRV, Herzegovina; HUN, Hungary; IND, India; KOR, Korea, LTU, Lithuania; LVA, Latvia; MEX, Mexico; MOR, Morocco; PER, Peru; POL, Poland; ROM, Romania; RUS, Russia; SVK, Slovakia; TWN, Taiwan; UKR, Ukraine; USA, United States; ZAF, South Africa.
Each row indicates the β-lactamase species identified in each region (e.g., CTX-M-2, SHV-12, TEM-1, and OXA-5).
C'pase, class A carbapenemase.
Thirty-one percent of the blaSHV genes were analyzed by pyrosequencing; and sequence information was derived only for nucleotides encoding residues at positions 35, 238, and 240. Therefore, these genes encode critical residues for the ESBL phenotype but have not been fully sequenced for unambiguous determination of the blaSHV derivative.
β-Lactamase names in italics indicate that sequence data were not sufficient to determine the specific derivative, so only the BLA family is listed.