TABLE 1.
In vitro antiviral activities of rupintrivir against HEV serotypes by three different methods
| HEV serotype | EC50 (μM)a
|
||
|---|---|---|---|
| FRET assay | PRA | DRA | |
| EV71 | 0.781 ± 0.028 | 0.791 ± 0.167 | 0.561 ± 0.083 |
| CVA16 | 0.331 ± 0.007 | 0.419 ± 0.032 | 0.270 ± 0.054 |
| CVB1 | 1.641 ± 0.216 | 1.725 ± 0.187 | 1.247 ± 0.177 |
| CVB2 | 0.857 ± 0.023 | 0.982 ± 0.290 | 0.783 ± 0.021 |
| CVB4 | 0.877 ± 0.100 | 0.843 ± 0.313 | 0.372 ± 0.023 |
| Echo9 | 0.434 ± 0.028 | 0.481 ± 0.105 | 0.360 ± 0.019 |
a
The results represent the mean ± standard deviation for triplicate experiments.