TABLE 4.
Daptomycin PKs in adult oncology patients with neutropenic fevera
| Parameter | Cmax (μg/ml) | Tmax (h) | C24 (μg/ml) | AUC0-∞ (μg·h/ml) | VSS (liter/kg) | CL (ml/h/kg) | t1/2 (h) | MRT (h) |
|---|---|---|---|---|---|---|---|---|
| Mean ± SD | 48.92 ± 12.63 | 0.6b | 5.67 ± 3.05 | 427.31 ± 134.73 | 0.18 ± 0.05 | 15.51 ± 5.65 | 8.75 ± 2.38 | 11.89 ± 3.36 |
| Range | 21.54-75.5 | 0.5-2.5 | 1.48-15.08 | 164.64-697.69 | 0.13-0.36 | 8.38-34.76 | 5.17-12.45 | 7.00-17.74 |
a
Data are means ± standard deviations and ranges for 28 patients (data for 1 outlier were excluded), unless indicated otherwise.
b
Median.