TABLE 1.

Effect of NA inhibitor treatment on mice infected with recombinant WT (A/H1N1) influenza virus^a

Regimen	Mean % of wt loss on day 5	Significance of wt loss vs the untreated group (P value)	Mortality rate (%)	Mean day of death	Lung viral titer ± SD on day 4 (PFU/lung)b	Significance of lung viral titer vs the untreated group (P value)
Untreated	17.4	NA	100	5.8	1.9 × 106 ± 0.1 × 106	NA
1 mg/kg oseltamivir 4 h preinfection	2.3	<0.01	0	NA	3.9 × 104 ± 1 × 104	<0.001
1 mg/kg A-322278 4 h preinfection	1.4	<0.01	0	NA	6 × 104 ± 2 × 104	<0.001
1 mg/kg oseltamivir 48 h p.i.	3.9	<0.01	11	5	5.2 × 104 ± 1.9 × 104	<0.001
1 mg/kg A-322278 48 h p.i.	9.1	<0.05	11	5	3.2 × 104 ± 1.3 × 104	<0.001
10 mg/kg oseltamivir 48 h p.i.	1.2	<0.001	0	NA	5.2 × 103 ± 1.0 × 103c	<0.001
10 mg/kg A-322278 48 h p.i.	9.5	<0.05	0	NA	3.0 × 104 ± 1.7 × 104	<0.001

^aNA, not applicable.

^bLung viral titers were done in triplicate. SD, standard deviation.

^cP < 0.05 versus 10 mg/kg A-322278 48 h p.i.