TABLE 2.

Effect of NA inhibitor treatment on mice infected with recombinant H274Y mutant (A/H1N1) influenza virus^a

Regimen	Mean % of wt loss on day 5	Significance of wt loss vs the untreated group (P value)	Mortality rate (%)	Mean day of death	Lung viral titer ± SD on day 4 (PFU/lung)b	Lung viral titer vs the untreated group (P value)
Untreated	22.2	NA	100	5.1	1.0 × 106 ± 0.3 × 106	NA
1 mg/kg oseltamivir 4 h preinfection	23.7	>0.05	100	5	1.9 × 105 ± 1.3 × 105	<0.001
1 mg/kg A-322278 4 h preinfection	10.8c	<0.01	0	NA	6.9 × 104 ± 0.7 × 104d	<0.001
10 mg/kg A-322278 4 h preinfection	5	<0.001	0	NA	3.5 × 104 ± 0.4 × 104	<0.001
1 mg/kg oseltamivir 48 h p.i.	20.1	>0.05	100	5.2	2.3 × 105 ± 0.9 × 105	<0.001
1 mg/kg A-322278 48 h p.i.	19	>0.05	75	5.4	8.3 × 104 ± 0.5 × 104e	<0.001
10 mg/kg oseltamivir 48 h p.i.	21.5	>0.05	75	5.1	1.4 × 105 ± 0.6 × 105	<0.001
10 mg/kg A-322278 48 h p.i.	15.6	<0.05	25	5	1.3 × 104 ± 0.3 × 104f	<0.001

^aNA, not applicable.

^bLung viral titers were done in triplicate. SD, standard deviation.

^cP < 0.001 versus 1 mg/kg oseltamivir at 4 h preinfection.

^dP < 0.001 versus 1 mg/kg oseltamivir at 4 h preinfection.

^eP < 0.001 versus 1 mg/kg oseltamivir at 48 h p.i.

^fP < 0.001 versus 10 mg/kg oseltamivir at 48 h p.i.