TABLE 3.

Discrimination criteria between PK models^a

Day	Model description	Mean ECV	Mean AIC	Mean r2	Mean residual variability (%)	Mean CL/F (liters/h)	Mean Vss/F (liters)
1	2 CPT, ka1	−6.3	3.4	0.940	7.2
	2 CPT, ka1, 2 ABS peaks	−4.6	10.7	0.913	6.7
	2 CPT, ka1, ka2	−9.5	3.0	0.993	2.7	45.6	2,629
	3 CPT, ka1	−2.4	15.2	0.930	8.0
	2 CPT, ka1, ka2, baseline Vss	−6	10.1	0.992	4.3
	2 CPT, ka1, ka2, saturable elimination	−2.3	19.5	0.927	7.3
	2 CPT, ka1, ka2, baseline Vss, saturable elimination	−2.3	19.4	0.928	6.9
21	2 CPT, ka1	16.9	49.8	0.911	17.1
	2 CPT, ka1, 2 ABS peaks	12.7	45.4	0.941	11.1
	2 CPT, ka1, ka2	8.9	39.8	0.960	7.2	22.6	1,494
	3 CPT, ka1	12.8	45.7	0.862	16.8
	2 CPT, ka1, ka2, baseline Vss	10.9	43.8	0.949	10
	2 CPT, ka1, ka2, saturable elimination	17.2	58.3	0.952	17.5
	2 CPT, ka1, ka2, baseline Vss, saturable elimination	20.2	64.4	0.913	20.6

^aThe selected model is in bold type. CPT, compartments; ABS, absorption; ECV, estimator criteria value.