TABLE 4.

Discrimination criteria between PK models (all data simultaneously fitted)^a

Model	Median ECV	Median AIC	Median r2	Median residual variability (%)
2 CPT; ka1; Tlag1 per dose	39.6	97.2	0.929	15.4
2 CPT; ka1; Tlag1, Tlag2 per dose; including peak 1%	37.3	98.5	0.945	17.2
2 CPT; ka1, ka2 and Tlag1, Tlag2 per dose; including peak 1%	36.4	98.9	0.954	14.9
2 CPT; ka1; Tlag1 per dose; Frel between day 1 and day 21	36.4	92.7	0.980	14.5
2 CPT; ka1, ka2; Tlag1, Tlag2 per dose; Frel for day 1	27.0	82.1	0.988	11.6
2 CPT; ka1, ka2; Tlag1, Tlag2 per dose; Frel for day 1 fixed based on the previous model, with Frel on CL/F for day 1	29.1	86.3	0.989	11.7
3 CPT; ka1; Tlag1 per dose	36.6	95.2	0.952	14.1
3 CPT; ka1, ka2; peak 1% the same for all days; Tlag1, Tlag2 per dose	33.9	97.7	0.949	15.3
3 CPT; ka1, ka2 and Tlag1, Tlag2 the same for all doses; including peak 1%	47.6	121.3	0.778	25.6
3 CPT; ka1, ka2 the same for all doses; Tlag1, Tlag2 and 2 peak 1% per dose	40.2	112.5	0.967	21.0

^aThe selected model is in bold type. CPT, compartments; ECV, estimator criteria value. α, distribution phase.