TABLE 5.
Elvucitabine PK parameters estimated using IT2S population compartmental analysesa
| Parameter(s) | Mean (%CV) | Median (range) |
|---|---|---|
| Peak 1% | 52.3 (32.8) | 47.8 (21.5-93.0) |
| Day 1, Tlag1 (h) | 0.363 (28.4) | 0.354 (0.218-0.612) |
| Day 1, Tlag2 (h) | 0.445 (42.8) | 0.492 (0.077-0.870) |
| Day 21, Tlag1 (h) | 0.341 (42.1) | 0.350 (0.069-0.721) |
| Day 21, Tlag2 (h) | 1.02 (91.7) | 0.729 (0.009-4.46) |
| ka1 (h−1) | 0.065 (64.6) | 0.057 (0.012-0.166) |
| ka2 (h−1) | 0.420 (22.5) | 0.404 (0.271-0.667) |
| % F for day 1 compared to that of other days | 55.4 (38.7) | 56.4 (17.0-90.5) |
| CL/F (liters/h) | 25.4 (48.0) | 23.4 (9.2-65.9) |
| Vc/F (liters) | 6.43 (75.4) | 5.87 (0.08-16.9) |
| CLD/F (liters/h) | 15.4 (28.9) | 15.4 (2.4-23.4) |
| Vp/F (liters) | 1,618 (47.8) | 1,398 (318-4,091) |
| Vss/F (liters) | 1,624 (47.6) | 1,396 (333-4,096) |
| λZ-HL (h) | 120 (23.0) | 115 (61.3-198) |
a
Residual variability, 15.7%. λZ-HL, terminal half-life.