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. Author manuscript; available in PMC: 2010 Jan 8.
Published in final edited form as: Cancer Lett. 2008 Jul 14;273(1):1–14. doi: 10.1016/j.canlet.2008.05.032

Table 3.

Semaphorin receptor complexes. Semaphorins can interact with complexes that include NRPs, plexins, various membrane proteins such as growth factor receptors and cell adhesion molecules (CAMs) which themselves interact. Asterisk: Sema3E is an exception, it cand bind D1-plexin directly.

receptor complex
ligand transducing unit binding unit additional unit
SEMA3 * plexin A NRP L1/Nr-CAM, integrin
SEMA4 plexin B + Met/ErbB2 plexin B CLCP1
SEMA5 plexin B plexin B
SEMA6 plexin A plexin A VEGFR/Off-Track
SEMA7 plexin C, integrin plexin C, integrin
VEGF VEGFR VEGFR, NRP
HGF Met NRP, Met
Galectin ? NRP
TGFβ ? NRP