Table 4.

Semaphorin involvment in diverse cancers. The very recent finding that SEMA3B inhibits tumor growth but fosters a prometastatic environment [95] adds complexity in the classification of SEMA3B as a pro- or anti-tumor semaphorin. exp., experiments

	SEMA	human tumor	in vitro exp.	in vivo exp.	effect	reference
pro-tumoral	3A	x	≠tumor cell lines	x	inhibits the immune response	135
		pancreas	x	x	correlates with shorter survival	136
	3B	glioblastoma	x	x	co-marker of poorer survival	137
	3C	x	ovarian cancer cells	x	ovarian cancer drug resistance	138
		ovary	x	x	correlates with shorter survival	139
		x	prostate cancer cells	x	invasive cellular growth	140
		x	lung cancer cells	x	overexpression in metastatic cells	109
	3E	breast	breast cancer cells	breast cancer cells	pro-metastatic	17,141
	4B	x	lung cancer cells	x	pro-migratory	57
	4D	leukemia	x	x	pro-proliferative	142
		x	leukemia cells	x	anti-apoptotic	143
		head and neck	h. and n. cancer cells	h. and n. cancer cells	pro-angiogenic	13,77
		x	breast cancer cells	x	invasive growth and pro-migratory	144
	5A	prostate	x	x	correlates with aggressiveness	121
	5B	kidney	x	x	increased expression in tumors	145
	5c	x	x	drosophila model	pro-metastatic	146
	6A	kidney	renal cancer cells	renal cancer cells	correlates with tumor vascularization	78
	6D	stomach	x	x	increased expression in tumors	147
anti-tumoral	3A	x	breast cancer cells	x	anti-migratory	148
		x	mesothelioma cells	x	negative retrocontrol of VEGF	149
		myeloma	myeloma cells	x	negative retrocontrol	104
		x	prostate cancer cells	x	anti-invasive in vitro	140
	3B	lung	x	x	gene deleted in tumors	5
		x	lung cancer cells	x	in vitro tumoral suppression	87
		x	lung cancer cells	x	lower expression in metastatic cells	90
		lung	x	x	lower expression in tumors	86
		x	lung cancer cells	x	pro-apoptotic	89
		x	ovarian cancer cells	ovarian cancer cells	in vivo tumoral suppression	88
	3F	lung	x	x	gene deleted in tumors	6,7
		lung	≠ cell lines	x	early expression loss	85,98
		lung	x	x	lower expression in tumors	85,98
		x	lung cancer cells	lung cancer cells	anti-angiogenic + tumoral suppression	81,82,101
		x	melanoma cells	melanoma cells	anti-metastatic	79
		x	HEK293 cells	HEK293 cells	anti-angiogenic	80
		x	x	murine fibrosarcoma cells	in vivo tumoral suppression	100
		x	breast cancer cells	x	anti-migratory	102,103
	4B	B-cell lymphoma	x	x	expression loss	150
	4D	x	breast cancer cells	x	anti-migratory	63