TABLE 2.

Effect of BM donor genotype on regenerated muscle fiber size and area of regeneration and residual necrosis

Donor BM → host	CSA (μm2)		Area of regeneration/necrosis: % TA (CTX)
	Regenerated fibers (CTX)	Mature fibers (NS)
WT → WT (HC)	1463 ± 34‡	2605 ± 105*	81 ± 6
WT → CCR2−/−	1367 ± 57‡	2665 ± 39*	83 ± 9
CCR2−/− → CCR2−/− (HC)	908 ± 65†	2855 ± 180*	86 ± 7
CCR2−/− → WT	940 ± 52†	2412 ± 148*	83 ± 7

Regenerated (centrally located nuclei) and mature (peripherally located nuclei) muscle fiber cross-sectional area and the area of muscle regeneration and residual necrosis were measured in a TA muscle specimen obtained at 21 days after CTX or NS injection. HC mice were used to control for the effect of BM transplantation. Data presented as means ± se; n = 4–7 mice/group. 

^*P ≤ 0.009 vs. regenerated fibers. 

^†P < 0.001 vs. WT → WT (HC). 

^‡P < 0.001 vs. CCR2^−/− → CCR2^−/− (HC). There were no significant differences among the four groups for mature fiber size or the area of regeneration and residual necrosis.