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. 2009 Feb;23(2):642–655. doi: 10.1096/fj.08-109686

Figure 4.

Figure 4.

Effect of voluntary exercise on the ratio of lean to fat mass over time. Values are averages ± se; n = 10–12 mice/group. ▪, MC4R KO sedentary group; □, MC4R KO RW group; •, WT littermate control sedentary group; ○, WT littermate RW group. Statistical analysis was performed using repeated-measures analysis with a Bonferroni post hoc test for the duration of the experimental weeks in terms of time (F7,208=11.7, P<0.0001) effects, time × genotype (F7,208=1.69, NS), time × exercise (F7,208=3.93, P<0.0001), and time × genotype × exercise (F7,208=0.65, NS) interactions. NS, nonsignificant. Statistically significant differences were observed between the sedentary MC4R KO mice and MC4R KO exercising mice as well as both the wild-type groups as indicated. *P < 0.05, **P < 0.01, ***P < 0.001.