TABLE 1.
Summary of immunohistochemistry for SphK1 and COX-2 in human colorectal tissues
| Tissue
|
n
|
SphK1 staining
|
COX-2 staining
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| – | ± | + | 2+ | – | ± | + | 2+ | ||
| Normal mucosa | 33 | 24 (73) | 9 (27) | 27 (82) | 6 (18) | ||||
| Adenoma | 14 | 3 (21) | 9 (64) | 2 (14) | 8 (57) | 4 (29) | 2 (14) | ||
| Adenocarcinoma | 33 | 5 (15) | 12 (36) | 16 (48) | 3 (9) | 13 (39) | 13 (39) | 4 (12) | |
| Metastasis | 14 | 6 (43) | 8 (57) | 6 (43) | 5 (36) | 3 (21) | |||
Values in parentheses represent percentages. −, no staining; ±, weak staining in <50% of cells; +, moderate staining in >50% of cells; 2+, strong staining in >50% of cells.