TABLE 1.
Summary of published AQP2 transgenic mouse models
| Model | Strain | Basal urine osmolality (mosmol) | Maximum urine osmolality (mosmol) | Urine output (ml/day) | Hydronephrosis | AQP2 localization | Survival | Ref. |
|---|---|---|---|---|---|---|---|---|
| AQP2T126M/T126M | CD1 | 220 | 220 | High | + | ER | 1 wk | 17 |
| AQP2F204V/F204V | C57BL/6 | 161 | 470 | High | + | ER | Adult | 24 |
| Inducible AQP2−/− | CD1 | 182 | 200 | 25 ml | + | — | Adult | 21 |
| AQP2763−772 del | C57BL/6 | 240 | 1120 | 5 ml | + | Basolateral membrane | Adult | 39 |
| AQP2S256L/S256L | C57BL/6 | 480 | 540 | High | + | Basolateral membrane | Adult | 23 |
| AQP2flx/flx Hoxb7-Cre | C57BL/6 | 170 | 170 | High | + | CNT apical membrane | Adult | 22 |
| AQP2Δ230/Δ230 | B6/129/SvJ | 193 | 200 | High | + | — | Adult | 38 |
| Inducible AQP2T126M/− | CD1 | 400 | 1000 | High | — | ER | Adult | — |