Figure 2.

BACHD mice exhibit stable polyglutamine repeats. A–D, Images of scans generated from GeneMapper analysis. Only one peak with 97 polyglutamines was identified in the germline (tail) (A) from BACHD mice. DNA from the cortex (B), striatum (C), and cerebellum (D) of BACHD mice at 12 months examined by GeneMapper analysis shows that mhtt in BACHD mice contains 97 repeats without any contractions or retractions. E, Table demonstrating that BACHD mice do not have any repeat expansion in the germline from maternal or paternal transmissions with both parents containing 97 polyQ repeats. The cortex, striatum, and cerebellum do not have any contractions or expansions in the polyQ region at 12 months.