Table 2.

Rectal cancer pooled analysis: Survival and relapse rates by stage of disease.^*

	Stage*		5-yr survival†		Relapse		Stage
Risk of relapse	TN	MAC	OS(%)	DFS(%)	Local(%)	Distant(%)	Dukes	TNM
Low‡	T1N0	A	~90	~90	≤ 5	~10	A	I
	T2N0	B1	~90	~90	≤ 5	~10	A	I
Intermediate	T1-2N1	C1	81	74	6	15	C	IIIA
	T3N0	B2	74	66	8	19	B	IIA
Moderately high	T1-2N2	C1	69	62	8	26	C	IIIC
	T4N0	B3	65	54	15	28	B	IIB
	T3N1	C2	61	50	11	34	C	IIIB
High	T3N2	C2	48	39	15	45	C	IIIC
	T4N1	C3	33	30	22	39	C	IIIB
	T4N2	C3	38	30	19	50	C	IIIC

Modified from Gunderson et al.¹¹

^*Stage of disease based on surgical and pathologic findings at the time of resection

^†Survival: Unadjusted Kaplan-Meier estimates

^‡Data derived from prior publications, as low-risk patients were not eligible for the three phase III trials in the pooled analysis

Abbreviations: DFS = disease-free survival; MAC = modified Aster-Coller; OS = overall survival; TNM = tumor, node, metastasis.