Table 5.

Outcomes by histologic feature in patients with T3N0 lesions treated with surgery alone at Massachusetts General Hospital (1968–1985).

		Relapse-free survival		Local control		Distant control
Histologic feature	No. pts	10-yr	(%) P value	10-yr	(%) P value	10-yr (%)	P value
Depth of invasion*
< 2 mm	33	87	.0007	93	.01	90	.0007
2–7.9 mm	62	57		75		65
≥ 8 mm	18	36		49		41
Vessel invasion
Absent	93	71	.0001	81	.029	79	.0001
Present	24	29		58		30
Grade
Well or moderate	79	70	.0005	82	.01	76	.0005
Poor	38	45		65		51

Modified from Willett et al¹⁴

Kaplan-Meier statistics and statistical significance determined by log-rank test

^*Unable to evaluate depth of invasion beyond muscularis propria into perirectal fat in 4 of 117 patients