Table 6.
Local relapse: TME alone vs. preoperative RT plus TME: Dutch phase III trial.
| TME alone
|
Preop RT + TME
|
||||
|---|---|---|---|---|---|
| Local relapse
|
Local relapse
|
||||
| Type of resection | No. pts | 2-yr (%) | No. pts | 2-yr (%) | P Value |
| Low anterior | 603 | 7.3 | 577 | 1.2 | < .001 |
| Abdominoperineal | 232 | 10.1 | 248 | 4.9 | .02 |
| Hartmann | 39 | 10.7 | 47 | 3.2 | .18 |
| TNM stage† | |||||
| I | 244 | 0.7 | 265 | .5 | .15 |
| II | 241 | 5.7 | 251 | 1.0 | .01 |
| III | 324 | 15.0 | 298 | 4.3 | < .001 |
| IV* | 48 | 23.8 | 47 | 10.1 | .25 |
| Total† | 874 | 8.2 | 872 | 2.4 | < .001 |
Modified from Katipeijn et al18
*
Distant metastases but complete local resection
†
Additional cases of unknown stage
Abbreviations: RT = radiotherapy; TME = total mesorectal excision; TNM = tumor, node, metastasis.