Table 4.
Prevalence of autoimmune diseases in first-degree relatives of CD probands (Group 2)
| Disease and Comparison Studies* | n | # observed (%) | Female:male ratio | Median age dx (range) | # expected | Standardized ratio (95% CI) |
|---|---|---|---|---|---|---|
| RA | 1272 | 8 (0.6) | 8:0 | 47.5 (18–71) | ||
| Study 1 [29] | ||||||
| Female age > 15 | 498 | 8 (1.6) | 6.5 | 1.2 (0.5–2.2) | ||
| Male age > 15 | 512 | 0 (0.0) | 3.1 | no reported cases | ||
| [Female + Male] age > 15 | 1010 | 8 (0.8) | 12.1 | 0.7 (0.3–1.2) | ||
| Study 2 [17] age > 16 yrs | 995 | 8 (0.8) | 8.6 | 0.9 (0.4–1.7) | ||
| JRA/JIA | 1272 | 4 (0.3) | 3:1 | 10.5 (4–17) | ||
| Study 1 [55] age ≤ 16 yrs | 1272 | 1 (0.07) | 0.2 | 5.3 (0.0–19.6) | ||
| Study 2 [56] | 1272 | 4 (0.3) | 0.7 | 5.7 (1.5–12.7) | ||
| Study 3 [54] age ≤ 16 yrs | 1272 | 1 (0.07) | 0.2 | 4.0 (0.0–19.6) | ||
| Hypothyroidism | 1272 | 34 (2.7) | 29:5 | 42.5 (12–78) | ||
| Study 1 [57] age ≥ 12 yrs | 1082 | 34 (2.7) | 49.8 | 0.7 (0.5–0.9) | ||
| Study 2 [58] age > 18 yrs | 953 | 34 (2.7) | 90.5 | 0.4 (0.2–0.5) | ||
| Study 3 [59] | ||||||
| female > 19 yrs | 457 | 29 (2.3) | 21.9 | 1.3 (0.9–1.9) | ||
| male > 19 yrs | 480 | 5 (0.4) | 4.3 | 1.2 (0.3–2.4) | ||
| IDDM | 1272 | 12 (0.9) | 1:3 | 11.5 (4–25) | ||
| Study 1 [60] | 1272 | 12 (0.9) | 3.8 | 3.2 (1.7–5.3) | ||
| Study 2 [17] Age < 20 yrs | 1272 | 10 (0.8) | 2.5 | 4.0 (2.0–7.0) | ||
| AA | 1272 | 4 (0.3) | 1:3 | 32.0 (19–41) | ||
| Study 1 [61] | 1272 | 4 (0.3) | 1.7 – 3.3 |
2.4 (0.8–6.8) 1.2 (0.4–3.6) |
||
| Study 2 [62] | 1272 | 4 (0.3) | 33.0 | 0.1 (0.0–0.3) | ||
| Total number of diseases | 1272 | 62 (4.9) | 1.6:1 | 27 (4–78) |
*
All ages unless specified