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Plasma glucose concentrations in pretreatment (closed circles) and posttreatment (open circles) studies of diabetic subjects receiving placebo (A) or vildagliptin (B). The protocol included a frequently sampled IVGTT from 0–240 min, a graded glucose infusion from 260 to 320 min, and an arginine bolus from 320 to 335 min. The acute insulin (C and D) and C-peptide (E and F) responses to an iv glucose bolus are shown for subjects receiving placebo (C and E) and vildagliptin (D and F).
