Table 2.
GRG effects on CD4+ recovery in those initiating HAARTat <350 CD4+ cells/mm3
| Pre-HAART CD4 count (cells/mm3)a |
GRG status |
Low versus moderate-high GRG CD4 difference (s.e.m.), P |
Low versus moderate GRG CD4 difference (s.e.m.), P |
||
|---|---|---|---|---|---|
| Low | Moderate-high | Moderate | |||
| <350 | 3.23 (0.21)b | 0.83 (0.22) | 0.80 (0.24) | 2.40 (0.29), 5.8 × 10−13 | 2.43 (0.31), 2.9 × 10−12 |
| <300 | 3.52 (0.21) | 0.28 (0.26) | 0.23 (0.28) | 3.24 (0.33), 5.0 × 10−16 | 3.29 (0.35), 6.2 × 10−12 |
| <250 | 3.47 (0.25) | −0.26 (0.27) | −0.33 (0.30) | 3.73 (0.37), 1.9 × 10−15 | 3.80 (0.39), 1.5 × 10−14 |
| <200 | 4.51 (0.24) | −0.23 (0.33) | −0.22 (0.33) | 4.74 (0.41), 3.6 × 10−16 | 4.73 (0.41), 8.1 × 10−16 |
| <150 | 4.60 (0.30) | −0.16 (0.37) | −0.16 (0.37) | 4.76 (0.47), 1.1 × 10−11 | 4.76 (0.47), 1.1 × 10−11 |
| <100 | 4.82 (0.34) | −0.06 (0.41) | −0.06 (0.41) | 4.88 (0.54), 1.5 × 10−9 | 4.88 (0.54), 1.5 × 10−9 |
| <50 | 4.59 (0.52) | −0.47 (0.90) | −0.47 (0.90) | 5.06 (1.04), 2.0 × 10−4 | 5.06 (1.04), 2.0 × 10−4 |
Data are for subjects from the WHMC HIV+ cohort who received HAART during chronic infection.
a
Pre-HAART CD4+ T cell count was the average of all CD4+ T cell counts during the 3 months before initiation of HAART.
b
Values are defined as in Table 1. Similar analyses were also conducted by using square-root-transformed CD4+ T cell counts (Supplementary Fig. 1f).