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. Author manuscript; available in PMC: 2009 Jan 26.
Published in final edited form as: J Acquir Immune Defic Syndr. 2008 Apr 15;47(5):592–596. doi: 10.1097/QAI.0b013e318163bd87

FIGURE 1.

FIGURE 1

Longitudinal plots describing HIV viral dynamics of 9 individuals who acquired HSV-2 infection. The intervals represent the calculated interval of time during which individuals could have acquired HSV-2 infection. The first point of the CI represents the date 2 weeks before the last negative HSV-2 EIA result so as to account for the potential seroconversion window time of HSV-2 EIA. The second point represents the date of the first positive HSV-2 EIA result. Note that the subject in panel 6 is the man who had a transient finding. The solid lines represent the fit of a generalized additive model, in which a nonparametric smooth was fitted to each individual, including a covariate indicating the first time point at which the individual was HSV-2–seropositive. Dotted lines represent 95% CIs. EDF for each curve are indicated, with higher values of EDF corresponding to more nonlinear curves.