Table 4.
Effects of treatment on body weight, BMD, and androgen-dependent organ weights
| Group | EB (μg/d) | S-23 (mg/d) | Animal numbers | Body weight (g) | BMD (g/cm2) | Prostate (percent of intact control) | Seminal vesicles (percent of intact control) | Levator ani muscle (percent of intact control) | Testis (percent of intact control) |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 6 | 423 ± 29 | 0.172 ± 0.0057 | 100 ± 20 | 100 ± 7.5 | 100 ± 15 | 100 ± 10 | ||
| 2 | 5 | 5 | 351 ± 8.0I | 0.181 ± 0.0036I | 46.9 ± 15I | 28.1 ± 12I | 62 ± 5.6I | 94 ± 10 | |
| 3 | 5 | 0.05 | 6 | 379 ± 20I | 0.188 ± 0.0036I,E | 34.4 ± 7.6I | 23.9 ± 7.6I | 90 ± 11E | 69 ± 14I,E |
| 4 | 5 | 0.1 | 6 | 376 ± 26I | 0.183 ± 0.0040I | 31.1 ± 6.6I | 21.8 ± 5.3I | 97 ± 15E | 34 ± 3.8I,E |
| 5 | 5 | 0.3 | 6 | 387 ± 25I,E | 0.188 ± 0.0085I | 45.1 ± 5.3I | 52 ± 8.7I,E | 100 ± 3.8E | 45 ± 3.9I,E |
| 6 | 5 | 0.5 | 6 | 351 ± 9.0I | 0.184 ± 0.0037I | 78.2 ± 5.6I,E | 89 ± 4.8E | 123 ± 8.5I,E | 63 ± 6.3I,E |
| 7 | 5 | 0.75 | 6 | 344 ± 11I | 0.183 ± 0.0036I | 94.7 ± 89.2E | 113 ± 12I,E | 131 ± 8.1I,E | 75 ± 7.2I,E |
Rats were treated for 70 d via sc injection. Data presented as mean ± sd. I and E, Significant difference between the group and intact control group or EB control group, respectively, as analyzed by single-factor ANOVA with P < 0.05.