Table 5.
Reversible effects on body weight and androgen-dependent organ weights
| Group | EB (μg/d) | S-23 (mg/d) | Animals | Body weight (g) | Prostate (percent of intact control) | Seminal vesicles (percent of intact control) | Testis (percent of intact control) | Levator ani muscle (percent of intact control) |
|---|---|---|---|---|---|---|---|---|
| 1 | 6 | 511.3 ± 24.4 | 100 ± 12.4 | 100 ± 8.9 | 100 ± 8.4 | 100 ± 8.2 | ||
| 2 | 5 | 5 | 487.8 ± 29.1 | 99.2 ± 4.1 | 95.6 ± 18.7 | 104.8 ± 6.6 | 102.6 ± 3.3 | |
| 3 | 5 | 0.05 | 6 | 503.8 ± 44.2 | 88.2 ± 12.3 | 95.4 ± 8.4 | 106.5 ± 5.2 | 96.5 ± 8.7 |
| 4 | 5 | 0.1 | 6 | 500.2 ± 35.4 | 79.4 ± 12.3I,E | 87.7 ± 11.6 | 99.8 ± 8.6 | 103.9 ± 14.3 |
| 5 | 5 | 0.3 | 6 | 506.7 ± 19.2 | 68.5 ± 7.7I,E | 92.8 ± 9.5 | 100.3 ± 6.0 | 85.8 ± 8.3I,E |
| 6 | 5 | 0.5 | 6 | 491.0 ± 19.8 | 73.7 ± 9.1I,E | 96.0 ± 10.3 | 100.4 ± 7.9 | 95.6 ± 8.3 |
| 7 | 5 | 0.75 | 6 | 478.2 ± 16.1I | 86.3 ± 9.4E | 105.2 ± 10.9 | 100.5 ± 6.0 | 98.7 ± 11.0 |
Rats were treated for 70 d via sc injection and then maintained without treatment for an additional 100 d. Data presented as mean ± sd. I and E, Significant difference between the group and intact control group or EB control group, respectively, as analyzed by single-factor ANOVA with P < 0.05.