Table 6.
Reversible effects on serum hormones, intratesticular sperm counts and fertility
| Group | EB (μg/d) | S-23 (mg/d) | Animals | LH (ng/ml) | FSH (ng/ml) | Sperm (million sperm/testis) | Number of pregnancies at 70 d | Number of pregnancies at 140 d |
|---|---|---|---|---|---|---|---|---|
| 1 | 6 | 0.64 ± 0.47 | 4.47 ± 1.15 | 72.42 ± 7.74 | 12/12 | 12/12 | ||
| 2 | 5 | 6a | 0.39 ± 0.16 | 3.76 ± 0.62 | 65.9 ± 9.52 | 12/12 | 10/12 | |
| 3 | 5 | 0.05 | 6b | 0.44 ± 0.24 | 3.92 ± 0.34 | 69.08 ± 8.39 | 2/12 | 8/12 |
| 4 | 5 | 0.1 | 6b | 0.41 ± 0.15 | 3.54 ± 0.84 | 67.58 ± 5.73 | 0/12 | 10/12 |
| 5 | 5 | 0.3 | 6 | 0.41 ± 0.1 | 3.37 ± 0.65 | 65.75 ± 5.68 | 2/12 | 10/12 |
| 6 | 5 | 0.5 | 6 | 0.42 ± 0.18 | 3.22 ± 0.8 | 65.42 ± 4.89 | 2/12 | 10/12 |
| 7 | 5 | 0.75 | 6 | 0.39 ± 0.22 | 3.51 ± 1.01 | 65.42 ± 4.19 | 6/12 | 10/12 |
Rats were treated for 70 d via sc injection and then maintained without treatment for an additional 100 d. Data presented as mean ± sd. I and E, Significant difference between the group and intact control group or EB control group, respectively, as analyzed by single-factor ANOVA with P < 0.05.
a
Serum was not available for analyses for two animals in this group (n = 4 for hormone values).
b
Serum was not available for analyses for one animal in this group (n = 5 for hormone values).