Table 2.
Quantitative histomorphometry of the secondary spongiosa of the distal femur in male WT and β -less mice
| 6 wk
|
16 wk
|
|||
|---|---|---|---|---|
| WT | β -less | WT | β -less | |
| OcS/BS (%) | 9.9 ± 1.2 | 5.6 ± 0.4a | 3.5 ± 1.2 | 6.3 ± 0.5 |
| NOc/BA (mm−1) | 1076 ± 151 | 585 ± 95a | 500 ± 166 | 808 ± 66 |
| MS/BS (%) | 26.3 ± 2.8 | 32.4 ± 5.9 | 37.4 ± 5.3 | 21.6 ± 4.1 |
| MAR (μm/d) | 1.29 ± 0.29 | 1.08 ± 0.10 | 1.09 ± 0.06 | 0.73 ± 0.12 |
| BFR (μm3/μm2 · d) | 0.36 ± 0.11 | 0.35 ± 0.08 | 0.41 ± 0.06 | 0.15 ± 0.03a |
Results are mean ± sem; n = 4 per group. BFR, Bone formation rate, surface referent; BS, bone surface; MAR, mineral apposition rate; MS, mineralizing surface; NOc/BA, osteoclast number per bone area; OcS, osteoclast surface.
a
P < 0.05 vs. WT.