Figure 4.

Serum T₄ and thyroglobulin antibodies during EAT of CBA/J mice. A, Thyroid function changes repeatedly after immunization; it decreases initially due to the nonthyroidal illness (NT) effect, remains low during the destructive phase of EAT, then increases transiently, and finally normalizes after d 70. B, IgG2a thyroglobulin-specific antibodies. Thyroglobulin antibodies increase as expected after immunization and remain elevated up to 3 months thereafter. C, T₄ levels positively and significantly correlates with thyroglobulin antibody levels.