Table 2.

Drug resistance patterns of predominant M. tuberculosis shared types as compared with genotype of CAS lineage.

clusters**	Sensitive n(%)a	Drug resistant isolates (n) as a percentage of total isolates in the clades (%)
		Rifampicin	Isoniazid	Streptomycin	Ethambutol	Pyrazinamide	Total
CAS	245 (45)	252 (46)	258 (47)	141 (26)	210 (39)	297 (55)	568
EAI	17 (35)	30 (61)	32 (65)	17 (35)	24 (49)	29 (59)	42
P value		0.08	0.06	0.12	0.13	0.28
Odds ratio		1.71	1.78	1.73	1.64	1.4
95% CI		0.92–3.19	0.96–3.30	0.86–3.51	0.86–3.14	0.75–2.62
Beijing	8 (32)	18 (72)	17 (68)	12 (48)	15 (60)	16 (64)	25
P value		0.071	0.1	0.041*	0.08	0.25
Odds ratio		2.18	2.01	2.6	2.18	1.65
95% CI		0.93–5.12	0.85–4.76	1.04–6.52	0.90–5.26	0.69–3.92
Haarlem	9 (60)	4 (27)	6 (40)	Not resistant	4 (27)	5 (33)	15
P value		0.16	0.25		0.67	0.16
Odds ratio		0.43	0.52		0.772	0.45
95% CI		0.13–1.42	0.17–1.59		0.23–2.55	0.15–1.38
T	6 (30)	8 (40)	9 (45)	5 (25)	5 (25)	7 (35)	23
P value		0.63	0.5	0.54	0.96	0.94
Odds ratio		1.29	1.42	1.44	0.97	0.96
95% CI		0.44–3.79	0.5–4.0	0.43–4.8	0.29–3.23	0.31–3.90
LAM	1 (50)	1 (50)	1 (50)	1 (50)	1 (50)	1 (50)	2
P value		0.98	0.97	0.69	0.91	0.89
Odds ratio		0.97	0.95	1.73	1.61	0.82
95% CI		0.06–15.03	0.05–15.26	0.10–27.99	0.07–18.76	0.05–13.25
Other Orphan-Pakb	20 (38)	19 (36)	21 (40)	9 (17)	19 (36)	13 (24)	46
P value		0.93	0.99	0.55	0.75	0.08
Odds ratio		0,97	0.99	0.78	1.1	0.53
95% CI		0.51–1.85	0.52–1.88	0.34–1.76	0.57–2.13	0.26–1.1
Orphan types	96 (47)	106 (52)	137 (67)	130 (63)	177 (86)	129 (63)	205
P value		0.67	0.058	0.001*	0.001*	0.52
Odds ratio		1.03	1.35	2.35	2.15	1.1
95% CI		0.77–1.48	0.99–1.85	1.68–3.29	1.57–2.93	0.81–1.1

^aSensitive to first line drugs (Rifampicin, Isoniazid, Streptomycin, Ethambutol and Pyrazinamide)

^bIncludes a total of 18 clusters

**Strain genotypes as listed in Fig. 1

* Significant difference compared to CAS genotypes