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. 2009 Jan 14;7:5. doi: 10.1186/1479-5876-7-5

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Copyright © 2009 Albini et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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AST lacks anti-angiogenic activity in animals gene targeted for the IL-12 receptor or for IL-12. AST was able to inhibit angiogenesis in wild-type (WT) animals but not in animals gene targeted for either the IL-12 specific receptor IL-12Rβ2 (IL-12Rβ2-/-) for the IL-12 signal system or for the IL-12 p40 subunit (IL-12p40-/-). Another angioegensis inhibitor, fenretinide (4HPR), retained anti-angiogenic activity. N = indicates the number of samples in each group. *** = P < 0.001 (Mann-Whitney) as compared to respective controls.