Table 3.
Loss of heterozygosity analysis of the FAT gene with 8 intragenic SNP markers in 20 grade II (A) and 20 grade IV (G) astrocytic tumors.
| Low grade Diffuse Astrocytoma (Grade II) | ||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP markers | A1 | A2 | A3 | A4 | A5 | A6 | A7 | A8 | A9 | A10 | A11 | A12 | A13 | A14 | A15 | A16 | A17 | A18 | A19 | A20 |
| rs2276930 | U | U | U | U | U | U | U | U | U | U | U | U | U | U | U | U | U | U | U | U |
| rs3733414 | NL | NL | U | U | U | L | L | NL | NL | NL | NL | NL | NL | NL | NL | NL | U | NL | NL | U |
| rs455600 | U | U | U | U | U | L | U | NL | NL | U | NL | U | NL | U | U | U | L | NL | U | U |
| rs213090 | NL | NL | U | U | NL | U | L | U | NL | U | NL | U | U | U | U | U | L | NL | L | U |
| rs450320 | U | L | U | L | NL | U | NL | U | L | NL | U | NL | U | NL | NL | NL | U | NL | U | L |
| rs7663350 | NL | NL | U | U | NL | NL | U | U | U | U | U | NL | U | U | U | NL | U | U | U | NL |
| rs1193110 | U | NL | U | U | U | U | U | U | U | U | U | U | U | U | U | U | U | U | NL | U |
| rs1298865 | U | U | U | U | U | U | U | U | U | U | U | U | U | U | U | U | U | U | U | U |
| Glioblastoma multiforme (Grade IV) | ||||||||||||||||||||
| SNP markers | G1 | G2 | G3 | G4 | G5 | G6 | G7 | G8 | G9 | G10 | G11 | G12 | G13 | G14 | G15 | G16 | G17 | G18 | G19 | G20 |
| rs2276930 | U | U | U | U | U | U | U | U | U | U | U | U | U | U | U | U | U | U | U | U |
| rs3733414 | U | U | U | U | NL | U | L | U | U | L | L | U | U | NL | NL | U | U | U | NL | NL |
| rs455600 | NL | U | NL | U | U | U | L | U | L | U | NA | NL | U | U | U | U | U | U | U | NL |
| rs213090 | L | L | U | U | U | U | U | NL | U | U | NL | U | NL | U | U | U | U | U | U | L |
| rs450320 | NL | NL | L | L | U | NL | U | L | NA | NL | L | U | U | NL | U | U | L | U | U | U |
| rs7663350 | U | U | NL | U | U | NL | U | U | NL | U | U | U | U | U | U | U | U | NL | NL | NL |
| rs1193110 | U | U | U | U | U | U | U | U | U | L | U | NL | U | U | U | U | U | U | U | U |
| rs1298865 | U | U | U | U | U | U | U | U | U | U | U | L | U | U | U | U | U | U | U | U |
L is loss of heterozygosity, NL is no loss of heterozygosity, U is uninformative and NA is not analysed. Loss of heterozygosity was detected in 42% of grade II and 58% of grade IV astrocytic tumors.