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. 2009 Jan 27;7(1):e1000025. doi: 10.1371/journal.pbio.1000025

Figure 1. Nrp1 Is Required for EC Adhesion to FN and FN Fibrillogenesis.

Figure 1

(A) Western blot analysis of protein expression in human ECs silenced for Nrp1 (sihNrp1) or transfected with control siRNA (siCtl).

(B–E) Comparison between siCtl (black lines) and sihNrp1 (red lines) transfected ECs adhering to different ECM proteins, i.e., FN (B), VT (C), COLL-I (D), and LN (E).

(F–G) Confocal scanning microscopy analysis of endogenous FN fibrils in siCtl (F) or sihNrp1 (G) transfected ECs. DAPI was used to stain nuclei. White bar in (F) corresponds to 50 μm.