Table 4.
Genes uniquely regulated by oxLDL
Gene | Symbol | Accession No. | Gene ID1 | Function2 | FC3vs PBS | FC vs oxLDL-IC | FC vs KLH-IC |
---|---|---|---|---|---|---|---|
Interferon-induced protein with tetratricopeptide repeats 1 |
IFIT1 | NM_001548 | 3434 | immune response | −2.58 | −3.77 | −3.25 |
Src-like-adaptor | SLA | U44403 | 6503 | intracellular signaling cascade | −2.45 | −2.72 | −2.32 |
Target of EGR1, member 1 (nuclear) | TOE1 | NM_025077 | 114034 | growth inhibitory activity | −1.93 | −2.45 | −2.15 |
AHA1, activator of heat shock 90kDa protein ATPase |
AHSA2 | AI831431 | 130872 | co-chaperone, response to unfolded protein | −3.20 | −2.35 | −1.87 |
Phosphoinositide-3-kinase, regulatory subunit 3 (p55, Gamma) |
PIK3R3 | BE622627 | 8503 | modulates the activity of the enzyme phosphatidylinositol 3-kinase activity | −1.89 | −1.76 | −2.31 |
Zinc finger protein 697 | ZNF697 | AW003092 | 90874 | regulation of transcription | 1.85 | 2.09 | 2.08 |
Oxidative stress induced growth inhibitor 1 |
OSGIN1 | NM_013370 | 29948 | growth inhibition, cell death | 2.54 | 2.57 | 2.58 |
Estrogen-responsive B box Protein | TRIM16 | NM_006470 | 10626 | enhancing the alternative secretion pathway of IL-1beta |
4.26 | 2.62 | 2.76 |
Ferritin, heavy polypeptide 1 | FTH1 | AA083483 | 2495 | inhibition of proliferation, ferric iron binding | 3.23 | 3.40 | 3.92 |
Sulfiredoxin 1 homolog | SRXN1 | AL121758 | 140809 | oxidoreductase activity | 3.26 | 3.49 | 3.56 |
Solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 |
SLC7A11 | AB040875 | 23657 | amino acid transport | 3.15 | 4.04 | 3.84 |
Adipose differentiation-related Protein | ADFP | BC005127 | 123 | long-chain fatty acid transport, sequestering of lipid | 4.20 | 4.42 | 4.42 |
Heme oxygenase (decycling) 1 | HMOX1 | NM_002133 | 3162 | oxidoreductase activity, iron ion binding | 95.67 | 58.49 | 25.90 |
NCBI Entrez Gene ID number
based on information from GO biological process annotations and PubMed.
FC, fold change